How bulky ligands control the chemoselectivity of Pd-catalyzed N-arylation of ammonia-Reference-Cited by-同舟云学术

How bulky ligands control the chemoselectivity of Pd-catalyzed N-arylation of ammonia

Published:2020 Issue:4 Volume:11 Page:1017-1025
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kim Seoung-Tae¹²³⁴⁵^ORCID,Kim Suyeon¹²³⁴⁵^ORCID,Baik Mu-Hyun⁵⁶³⁴¹^ORCID

Affiliation:

1. Department of Chemistry

2. Korea Advanced Institute of Science and Technology (KAIST)

3. Daejeon 34141

4. Republic of Korea

5. Center for Catalytic Hydrocarbon Functionalizations

6. Institute for Basic Science (IBS)

Abstract

Steric bulk has been recognized as a central design principle for ligands in the widely utilized Buchwald–Hartwig amination. This mechanistic study reveals how this steric effect manipulates the reaction pathway and determines the chemoselectivity.

Funder

Institute for Basic Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC03095F

Reference51 articles.

1. Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

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3. Origins, Current Status, and Future Challenges of Green Chemistry