Carborane clusters increase the potency of bis-substituted cyclam derivatives against <i>Mycobacterium tuberculosis</i>-Reference-Cited by-同舟云学术

Carborane clusters increase the potency of bis-substituted cyclam derivatives against Mycobacterium tuberculosis

Published:2022 Issue:10 Volume:13 Page:1234-1238
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Smith Nicholas¹,Quan Diana²³,Nagalingam Gayathri²³,Triccas James A.²³,Rendina Louis M.¹⁴^ORCID,Rutledge Peter J.¹^ORCID

Affiliation:

1. School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia

2. Sydney Institute of Infectious Diseases and Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia

3. School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia

4. The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, Sydney, NSW 2006, Australia

Abstract

Bis-substituted cyclam derivatives have recently emerged as a promising new class of antibacterial agents, displaying excellent activity against drug-resistant Mycobacterium tuberculosis (Mtb). Carborane pendants enhance this activity.

Funder

National Health and Medical Research Council

Australian Government

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00150K

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