Structure-based discovery of potent inhibitors of Axl: design, synthesis, and biological evaluation-Reference-Cited by-同舟云学术

Structure-based discovery of potent inhibitors of Axl: design, synthesis, and biological evaluation

Published:2022 Issue:10 Volume:13 Page:1246-1264
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Wu Shuang¹²³,Liao Min³⁴,Li Minxiong³,Sun Mingming²³,Xi Ning²³^ORCID,Zeng Youlin¹^ORCID

Affiliation:

1. Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), Hunan Normal University, Changsha 410081, PR China

2. Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, Zhejiang, 315211, China

3. Sunshine Lake Pharmaceutical Co. Ltd, Dongyangguang Hi-tech Park, Dongguan, Guangdong, 523871, China

4. School of Chemistry & Chemical Engineering, Guangxi University, Nanning 530004, China

Abstract

Commonly overexpressed in many cancers and associated with tumor growth, metastasis, drug resistance, and poor overall survival, Axl has emerged as a promising target for cancer therapy.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00153E

Reference29 articles.

1. Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors

2. Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site

3. Role of Gas6/Axl signaling in lens epithelial cell proliferation and survival

4. AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective

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