Development of novel oxygen carriers by coupling hemoglobin to functionalized multiwall carbon nanotubes

Author:

Zhang Ke12345,Xiao Xiongfu12345,Li Linhao12345,Fan Yubo12345,Cai Qiang6784,Lee In-Seop9101112,Li Xiaoming12345ORCID

Affiliation:

1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education

2. School of Biological Science and Medical Engineering, Beihang University

3. Beijing 100083

4. China

5. Beijing Advanced Innovation Center for Biomedical Engineering

6. Key Laboratory of Advanced Materials of Ministry of Education

7. Tsinghua University

8. Beijing 100084

9. Institute of Natural Sciences

10. Yonsei University

11. Seoul 03722

12. South Korea

Abstract

Heparization could significantly improve the Hb-loading capability and biocompatibility of MWCNTs, and a novel oxygen carrier was prepared by coupling Hb with MWCNT-Hep through electrostatic interactions.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Fok Ying Tung Education Foundation

State Key Laboratory of New Ceramics and Fine Processing

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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