Rational design of ratiometric and lysosome-targetable AIE dots for imaging endogenous HClO in live cells

Author:

Hong Yongxiang12345,Wang Hong56789,Xue Mingju56789,Zhang Peisheng56789ORCID,Liu Wanqiang56789,Chen Shu56789,Zeng Rongjin56789,Cui Jiaxi1011121314,Gao Yong1234ORCID,Chen Jian56789ORCID

Affiliation:

1. College of Chemistry and Key Laboratory of Polymeric Materials & Application Technology of Hunan Province

2. and Key Laboratory of Advanced Functional Polymeric Materials of College of Hunan Province

3. Xiangtan University

4. China

5. Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education

6. Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers

7. Hunan Province College Key Laboratory of QSAR/QSPR

8. Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion

9. School of Chemistry and Chemical Engineering

10. INM-Leibniz Institute for New Materials Campus D2 2

11. 66123 Saarbrícken

12. Germany

13. Institute of Fundamental and Frontier Sciences

14. University of Electronic Science and Technology of China

Abstract

A novel lysosome-targetable ratiometric AIE nanoprobe was rationally designed and synthesized for sensing of endogenous HClO levels in live cells.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

China Postdoctoral Science Foundation

State Key Laboratory of Chemo/Biosensing and Chemometrics

South China University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

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