Streamlined construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation in solution and on DNA-Reference-Cited by-同舟云学术

Streamlined construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation in solution and on DNA

Published:2021 Issue:16 Volume:12 Page:5804-5810
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yang Peng¹²³⁴⁵,Wang Xuan⁶⁷⁸⁹⁵,Li Bo¹²³⁴⁵,Yang Yixuan⁶⁷⁸⁹⁵,Yue Jinfeng⁶⁷⁸⁹⁵,Suo Yanrui⁶⁷⁸⁹⁵,Tong Huarong¹²³⁴⁵,He Gang¹²³⁴⁵,Lu Xiaojie⁶⁷⁸⁹⁵^ORCID,Chen Gong¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory and Institute of Elemento-Organic Chemistry

2. College of Chemistry

3. Nankai University

4. Tianjin 300071

5. China

6. State Key Laboratory of Drug Research

7. Shanghai Institute of Materia Medica

8. Chinese Academy of Sciences

9. Shanghai 201203

Abstract

A highly efficient and versatile method for construction of peptide macrocycles via palladium-catalyzed intramolecular S-arylation of alkyl and aryl thiols with aryl iodides under mild conditions is developed.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin City

Ministry of Education of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00789K

Reference98 articles.

1. The exploration of macrocycles for drug discovery — an underexploited structural class