Suppressing crucial oncogenes of leukemia initiator cells by major royal jelly protein 2 for mediating apoptosis in myeloid and lymphoid leukemia cells-Reference-Cited by-同舟云学术

Suppressing crucial oncogenes of leukemia initiator cells by major royal jelly protein 2 for mediating apoptosis in myeloid and lymphoid leukemia cells

Published:2022 Issue:17 Volume:13 Page:8951-8966
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Abu-Serie Marwa M.¹^ORCID,Habashy Noha H.²^ORCID

Affiliation:

1. Department of Medical Biotechnology, Genetic Engineering, and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg EL-Arab 21934, Alexandria, Egypt

2. Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt

Abstract

Apis mellifera major royal jelly protein 2 suppressed leukemia-initiating stem cell (LIC)-related oncogenes, MMP10 and HDAC8 activities, as well as CD34+ LICs in myeloid and lymphoid leukemia cells, resulting in their cell cycle arrest and apoptosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00999D

Reference49 articles.

1. Epigenetic mechanisms underlying the therapeutic effects of HDAC inhibitors in chronic myeloid leukemia

2. Targeting transcription factors in acute myeloid leukemia

3. EVI1 dysregulation: impact on biology and therapy of myeloid malignancies

4. Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia

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