Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae

Published:2016 Issue:5 Volume:12 Page:1432-1435
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Zhang Jiantao¹²³⁴⁵,Wu Chaochen¹²³⁴,Sheng Jiayuan¹²³⁴,Feng Xueyang¹²³⁴

Affiliation:

1. Department of Biological Systems Engineering

2. Virginia Polytechnic Institute and State University

3. Blacksburg

4. USA

5. Department of Pharmacology & Toxicology

Abstract

We report for the first time that 5-hydroxytryptophan can be synthesized in Saccharomyces cerevisiae by heterologously expressing prokaryotic phenylalanine 4-hydroxylase or eukaryotic tryptophan 3/5-hydroxylase, together with enhanced synthesis of MH4 or BH4 cofactors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MB/C5MB00888C

Reference14 articles.

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