A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growthviadownregulating YAP-mediated autophagy-Reference-Cited by-同舟云学术

A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growthviadownregulating YAP-mediated autophagy

Published:2019 Issue:6 Volume:10 Page:3748-3757
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wang Lihua¹²³⁴⁵,Zhu Zheng⁶³⁷⁵,Han Lei⁶³⁷⁵,Zhao Liqian⁶³⁷⁵,Weng Jialei⁶³⁷⁵,Yang Hongbao⁸⁹⁴⁵,Wu Shijia⁸⁹⁴⁵,Chen Kaiyuan⁸⁹⁴⁵,Wu Liang¹⁰¹¹⁴⁵,Chen Tongke⁶³⁷⁵^ORCID

Affiliation:

1. School of Ophthalmology and Optometry

2. Eye Hospital

3. Wenzhou Medical University

4. Wenzhou 325000

5. China

6. Laboratory Animal Centre

7. Wenzhou

8. Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province

9. The First Affiliated Hospital of Wenzhou Medical University

10. Department of Pathology

11. First Affiliated Hospital of WenZhou Medical University

Abstract

HCC is a common cancer type in the world. Here, we found WZ35, a novel derivative of curcumin, could notably suppress HCC cell growthviainhibiting YAP controlled autophagy, highlighting the potent anti-tumor activity of WZ35 in liver cancer therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/FO/C8FO02448K

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