Improved thrombin binding aptamer analogues containing inversion of polarity sites: structural effects of extra-residues at the ends-Reference-Cited by-同舟云学术

Improved thrombin binding aptamer analogues containing inversion of polarity sites: structural effects of extra-residues at the ends

Published:2016 Issue:32 Volume:14 Page:7707-7714
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Virgilio A.¹²³⁴,Amato T.¹²³⁴,Petraccone L.⁵²⁶⁴,Filosa R.⁷⁸⁹⁴,Varra M.¹²³⁴,Mayol L.¹²³⁴,Esposito V.¹²³⁴,Galeone A.¹²³⁴

Affiliation:

1. Department of Pharmacy

2. University of Naples Federico II

3. 80131 Naples

4. Italy

5. Department of Chemical Sciences

6. I-80126 Naples

7. Department of Experimental Medicine

8. Second University of Naples

9. 80138 Naples

Abstract

TBA analogues containing 3′–3′ or 5′–5′ extra-residues adopt chair-like G-quadruplex structures in which a 3′–3′ phosphodiester bond is fundamental for stability.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00931J

Reference36 articles.

1. Aptamers: Molecules of great potential

2. G4 Aptamers: Trends in Structural Design

3. G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application

4. Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.

5. Biophysical and biological properties of quadruplex oligodeoxyribonucleotides

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2. G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects;Pharmacology & Therapeutics;2021-01

3. Improving Thermodynamic Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Incorporation of 8-trifluoromethyl-2′-deoxyguanosine;Journal of Medicinal Chemistry;2020-12-08

4. Investigating the properties of TBA variants with twin thrombin binding domains;Scientific Reports;2019-06-24

5. Structural and mechanistic insights into modified G-quadruplex thrombin-binding DNA aptamers;Biochemical and Biophysical Research Communications;2019-06