Proof-of-concept optimization of a copper-mediated <sup>18</sup>F-radiosynthesis of a novel MAGL PET tracer on a high-throughput microdroplet platform and its macroscale translation-Reference-Cited by-同舟云学术

Proof-of-concept optimization of a copper-mediated ¹⁸F-radiosynthesis of a novel MAGL PET tracer on a high-throughput microdroplet platform and its macroscale translation

Published:2023 Issue:21 Volume:23 Page:4652-4663
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Lu Yingqing¹²³^ORCID,He Yingfang⁴,Schibli Roger⁴,Mu Linjing⁴^ORCID,van Dam R. Michael¹²³^ORCID

Affiliation:

1. Crump Institute for Molecular Imaging, University of California Los Angeles (UCLA), Los Angeles, CA, USA

2. Department of Molecular & Medical Pharmacology, UCLA, Los Angeles, CA, USA

3. Physics and Biology in Medicine Interdepartmental Graduate Program, UCLA, Los Angeles, CA, USA

4. Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland

Abstract

Arrays of parallel droplet reactions enable high-speed optimization, and discovered conditions can be immediately scaled for use on conventional instruments.

Funder

University of California, Los Angeles

National Institutes of Health

National Institute of Biomedical Imaging and Bioengineering

National Cancer Institute

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D3LC00735A