Synthesis of 3′-deoxy-3′-fluorothymidine (FLT) 5′-O-glucuronide: a reference standard for imaging studies with [18F]FLT-Reference-Cited by-同舟云学术

Synthesis of 3′-deoxy-3′-fluorothymidine (FLT) 5′-O-glucuronide: a reference standard for imaging studies with [18F]FLT

Published:2014 Issue:7 Volume:5 Page:984-988
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Harnor Suzannah J.¹²³⁴⁵,Rennison Tommy¹²³⁴⁵,Galler Martin¹²⁶⁴⁵,Cano Celine¹²³⁴⁵,Griffin Roger J.¹²³⁴⁵,Newell David R.¹²⁶⁴⁵,Golding Bernard T.¹²³⁴⁵

Affiliation:

1. Newcastle Cancer Centre

2. Northern Institute for Cancer Research

3. School of Chemistry

4. Newcastle University

5. Newcastle upon Tyne, UK

6. Medical School

Abstract

The de novo synthesis of 3′-deoxy-3′-fluorothymidine-5′-O-glucuronide enabled both the analysis of this reference standard by HPLC and identification of the metabolite in a blood sample from a patient administered [¹⁸F]FLT.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C3MD00381G

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