Identification of an inhibitor of the ubiquitin–proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function-Reference-Cited by-同舟云学术

Identification of an inhibitor of the ubiquitin–proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function

Published:2014 Issue:3 Volume:5 Page:376-385
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Haglund Caroline¹²³⁴,Mohanty Chitralekha⁵⁶⁷⁴,Fryknäs Mårten¹²³⁴,D'Arcy Padraig⁵⁶⁷⁴,Larsson Rolf¹²³⁴,Linder Stig¹²³⁴⁵,Rickardson Linda¹²³⁴

Affiliation:

1. Department of Medical Sciences (Division of Clinical Pharmacology)

2. Uppsala University

3. SE-751 85 Uppsala

4. Sweden

5. Department of Oncology-Pathology

6. Karolinska Institutet

7. SE-171 76 Stockholm

Abstract

The ubiquitin–proteasome system (UPS) represents one of the most promising therapeutic targets in oncology to emerge in recent years.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C3MD00386H

Reference44 articles.

1. The proteasome: a suitable antineoplastic target

2. Structural Features of the 26 S Proteasome Complex

3. Diversity of degradation signals in the ubiquitin–proteasome system

4. Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

5. Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

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