Study on drug substance degradation under headspace GC conditions of residual solvent analysis-Reference-Cited by-同舟云学术

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Study on drug substance degradation under headspace GC conditions of residual solvent analysis

Published:2023 Issue:7 Volume:15 Page:901-905
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Zhao Hua¹^ORCID,Phillipson Doug²,Li Jiangwei¹^ORCID,Wu Frank¹^ORCID

Affiliation:

1. Neurocrine Biosciences Inc, 12780 El Camino Real, San Diego, CA 92130, USA

2. 14148 Bahama Cove, Del Mar, CA 92014, USA

Abstract

The mechanism and kinetics of the isobutyraldehyde formation had been studied when the drug substance that contains an amino acid group is under the headspace oven temperature during residual solvent testing.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AY/D2AY02013K

Reference4 articles.

1. H.Lee , Control of chloroethane in raw materials and drug substances using headspace/gas chromatography analysis , Pharmaceutical Industry Practices on Genotoxic Impurities . 2014 , p. 14

2. Kinetics and Mechanism of Gas-Phase Thermolysis Using Headspace-Gas Chromatographic Analysis

3. The Strecker Degradation of Amino Acids: Newer Avenues for Flavor Formation

4. The reaction kinetics for the formation of Strecker aldehydes in low moisture model systems and in plant powders

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