Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding-Reference-Cited by-同舟云学术

Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding

Published:2022 Issue:36 Volume:14 Page:13261-13273
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Ahmad Ashfaq¹²^ORCID,Georgiou Panagiotis G.¹^ORCID,Pancaro Alessia³⁴^ORCID,Hasan Muhammad¹^ORCID,Nelissen Inge³⁴,Gibson Matthew I.¹²^ORCID

Affiliation:

1. Department of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, UK

2. Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, UK

3. Health Unit, Flemish Institute for Technological Research (VITO), Boeretang 200, Mol, BE-2400, Belgium

4. Dynamic Bioimaging Lab, Advanced Optical Microscopy Centre and Biomedical Research Institute, Hasselt University, Agoralaan C, Diepenbeek, BE-3590, Belgium

Abstract

Upon exposure to biological fluids, the fouling of nanomaterial surfaces results in non-specific capture of proteins, which is particularly important when in contact with blood serum for in vivo and ex vivo applications.

Funder

Vlaamse Instelling voor Technologisch Onderzoek

H2020 Marie Skłodowska-Curie Actions

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR01818G

Reference64 articles.

1. The regulatory power of glycans and their binding partners in immunity