Intranasal delivery of berberine via in situ thermoresponsive hydrogels with non-invasive therapy exhibits better antidepressant-like effects-Reference-Cited by-同舟云学术

Intranasal delivery of berberine via in situ thermoresponsive hydrogels with non-invasive therapy exhibits better antidepressant-like effects

Published:2020 Issue:10 Volume:8 Page:2853-2865
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Wang Qiang-Song¹²³⁴⁵,Li Kefeng⁶⁷⁸⁹¹⁰,Gao Li-Na¹¹¹²¹³¹⁴⁵,Zhang Ye¹¹¹²¹³¹⁴⁵,Lin Ke-Ming¹¹¹²¹³¹⁴⁵,Cui Yuan-Lu¹¹¹²¹³¹⁴⁵^ORCID

Affiliation:

1. Tianjin Key Laboratory of Biomedical Materials

2. Institute of Biomedical Engineering

3. Chinese Academy of Medical Science & Peking Union Medical College

4. Tianjin 300192

5. PR China

6. School of Medicine

7. University of California

8. San Diego (UCSD)

9. San Diego

10. USA

11. Tianjin State Key Laboratory of Modern Chinese Medicine

12. Research Center of Traditional Chinese Medicine

13. Tianjin University of Traditional Chinese Medicine

14. Tianjin

Abstract

Intranasal delivery of thermoresponsive hydrogels can improve the bioavailability of berberine in the brain, so as to improve the antidepressant effect.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/C9BM02006C

Reference40 articles.

1. The Role of Natural Product Chemistry in Drug Discovery

2. The re-emergence of natural products for drug discovery in the genomics era

3. Berberine: a potential phytochemical with multispectrum therapeutic activities

4. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders

5. The Involvement of P-Glycoprotein in Berberine Absorption

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