A magnetic mucus-penetrating nanoagent boosting phlegm elimination for inhalation injury treatment-Reference-Cited by-同舟云学术

A magnetic mucus-penetrating nanoagent boosting phlegm elimination for inhalation injury treatment

Published:2024 Issue:18 Volume:12 Page:4713-4726
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Waheed Saquib¹²,Huang Guangtao¹,Shekh Mehdihasan³^ORCID,Wang Feng¹,Li Zhibin¹^ORCID,Wu Jun¹⁴

Affiliation:

1. Department of Burn and Plastic Surgery, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, 518035, China

2. Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518060, China

3. College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China

4. Human Histology & Embryology Section, Department of Surgery, Dentistry, Paediatrics & Gynaecology, University of Verona Medical School, 37134, Verona, Venetia, Italy

Abstract

This study explores using magnetic nanoparticles (MNPs) with NIPAM and PEG coatings, loaded with ambroxol (MNP@PNIPAM-AH@PEG), for inhalation injury treatment. PEG aids mucus penetration, and NIPAM enhances drug release, resolving sputum and reducing inflammation.

Funder

Natural Science Foundation of Guangdong Province

National Fund for Fostering Talents of Basic Science

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D4BM00640B

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