Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid

Author:

Joo Jeong Chan12345ORCID,Khusnutdinova Anna N.6789,Flick Robert6789,Kim Taeho6789,Bornscheuer Uwe T.1011121314,Yakunin Alexander F.6789,Mahadevan Radhakrishnan6789

Affiliation:

1. Center for Bio-based Chemistry

2. Division of Convergence Chemistry

3. Korea Research Institute of Chemical Technology

4. Daejeon 34114

5. Republic of Korea

6. Department of Chemical Engineering and Applied Chemistry

7. University of Toronto

8. ON M5S 3E5

9. Canada

10. Institute of Biochemistry

11. Department of Biotechnology & Enzyme Catalysis

12. Greifswald University

13. 17487 Greifswald

14. Germany

Abstract

We demonstrate the first enzymatic hydrogenation of 2-hexenedioic acid and muconic acid to adipic acid using enoate reductases (ERs).

Funder

Natural Sciences and Engineering Research Council of Canada

Ministry of Trade, Industry and Energy

Genome Canada

Ontario Genomics Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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