Dual functional amphiphilic sugar-coated AIE-active fluorescent organic nanoparticles for the monitoring and inhibition of insulin amyloid fibrillation based on carbohydrate–protein interactions

Author:

Ji Yan-ming1,Zhang Wenyan23,Zhang Jing-dong1,Li Xia-fen1,Yu Fan-dong1,Li Cui-yun1,Liu Guang-jian1ORCID,Xing Guo-wen1ORCID

Affiliation:

1. College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China

2. Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China

3. Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, Beijing 100083, P. R. China

Abstract

A highly practical strategy was developed to provide a series of dual functional sugar-coated AIE-active fluorescent organic nanoparticles for the detection and inhibition of insulin fibrillation based on carbohydrate–protein interactions.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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