Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects

Author:

Everett James12345,Collingwood Joanna F.678910ORCID,Tjendana-Tjhin Vindy678910ORCID,Brooks Jake678910ORCID,Lermyte Frederik678910ORCID,Plascencia-Villa Germán111213ORCID,Hands-Portman Ian14159105,Dobson Jon1617181319ORCID,Perry George201213ORCID,Telling Neil D.12345ORCID

Affiliation:

1. Institute for Science and Technology in Medicine

2. Thornburrow Drive

3. Keele University

4. Staffordshire

5. UK

6. Warwick Engineering in Biomedicine

7. School of Engineering

8. Library Road

9. University of Warwick

10. Coventry

11. Department of Physics and Astronomy. The University of Texas at San Antonio (UTSA)

12. San Antonio

13. USA

14. School of Life Sciences

15. Gibbet Hill Campus

16. Department of Materials Science and Engineering

17. University of Florida

18. Gainesville

19. J. Crayton Pruitt Family Department of Biomedical Engineering

20. Department of Biology and UTSA Neurosciences Institute. The University of Texas at San Antonio (UTSA)

Abstract

Synchrotron soft X-ray nano-imaging and spectromicroscopy reveals iron and calcium biomineralization in Alzheimer's disease amyloid plaques.

Funder

Engineering and Physical Sciences Research Council

Alzheimer's Association

University of Warwick

University of Texas at San Antonio

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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