Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains-Reference-Cited by-同舟云学术

Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains

Published:2015 Issue:4 Volume:6 Page:653-664
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

He Xiaomeng¹²³⁴,Jiang Yan¹²³⁴,Zhang Yongqiang¹²³⁴,Wu Shanchao¹²³⁴,Dong Guoqiang¹²³⁴,Liu Na¹²³⁴,Liu Yang¹²³⁴,Yao Jianzhong¹²³⁴,Miao Zhenyuan¹²³⁴,Wang Yan¹²³⁴,Zhang Wannian¹²³⁴,Sheng Chunquan¹²³⁴

Affiliation:

1. School of Pharmacy

2. Second Military Medical University

3. Shanghai 200433

4. China

Abstract

A series of novel triazole antifungal agents containing piperidine-oxadiazole side chains were designed and synthesized. Compound 11b was highly active against Candida albicans with a MIC value of 0.016 μg mL⁻¹.

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00505H

Reference29 articles.

1. Invasive fungal infections: a review of epidemiology and management options

2. Current challenges in the management of invasive fungal infections