Cross-dehydrogenative coupling enables enantioselective access to CF3-substituted all-carbon quaternary stereocenters

Author:

Pan Xiaoguang1234,Wang Zehua5264,Kan Linglong5264,Mao Ying1234,Zhu Yasheng1234,Liu Lei12345ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Shandong University

3. Jinan 250012

4. China

5. School of Chemistry and Chemical Engineering

6. Jinan 250100

Abstract

A cross-dehydrogenative coupling (CDC) strategy for enantioselective access to acyclic CF3-substituted all-carbon quaternary stereocenters has been established.

Funder

Fok Ying Tung Education Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference89 articles.

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2. Fluorine in Medicinal Chemistry and Chemical Biology , ed. I. Ojima , Wiley , Chichester, U.K. , 2009

3. Fluorine in Pharmaceuticals: Looking Beyond Intuition

4. The Many Roles for Fluorine in Medicinal Chemistry

5. Fluorinated Carbonyl and Olefinic Compounds:  Basic Character and Asymmetric Catalytic Reactions

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