The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity-Reference-Cited by-同舟云学术

The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity

Published:2021 Issue:12 Volume:12 Page:5465-5477
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Wang Fenghua¹²³⁴⁵,Wang Ying¹²³⁴⁵,Jiang Luying¹²³⁴⁵,Wang Wenqian¹²³⁴⁵,Sang Jingcheng¹²³⁴⁵,Wang Xinyu¹²³⁴⁵,Lu Fuping¹²³⁴⁵,Liu Fufeng¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Food Nutrition and Safety

2. Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology; College of Biotechnology

3. Tianjin University of Science & Technology

4. Tianjin 300457

5. P. R. China

Abstract

A safe food additive, fast green FCF, was identified and characterized to be capable of inhibiting α-synuclein fibrillogenesis, disassembling mature fibrils and reducing the related cytotoxicity.

Funder

National Natural Science Foundation of China

Tianjin Science and Technology Committee

Tianjin University of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO03301D

Reference59 articles.

1. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies