Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation

Published:2022 Issue:5 Volume:13 Page:568-584
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Cristancho Ortiz Cindy Juliet¹,de Freitas Silva Matheus¹,Pruccoli Letizia²,Fonseca Nadur Nathália³,de Azevedo Luciana Luíza³,Kümmerle Arthur Eugen³^ORCID,Guedes Isabella Alvim⁴^ORCID,Dardenne Laurent Emmanuel⁴,Leomil Coelho Luiz Felipe⁵,Guimarães Marcos J.⁶,da Silva Fernanda M. R.⁶,Castro Newton⁶^ORCID,Gontijo Vanessa Silva¹,Rojas Viviana C. T.⁷,de Oliveira Merelym Ketterym⁷,Vilela Fabiana Cardoso⁷,Giusti-Paiva Alexandre⁷^ORCID,Barbosa Gisele⁸,Lima Lídia Moreira⁸^ORCID,Pinheiro Gabriela Beserra⁹,Veras Letícia Germino⁹,Mortari Márcia Renata⁹,Tarozzi Andrea¹²,Viegas Claudio¹^ORCID

Affiliation:

1. PeQuiM-Laboratory of Research in Medicinal Chemistry, Federal University of Alfenas, 2600 Jovino Fernandes Sales Ave., Alfenas, MG 37130-840, Brazil

2. Department for Life Quality Studies, University of Bologna‘Alma Mater Studiorum’, 237 Corso d'Augusto St., 47921 Rimini, Italy

3. Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Seropédica, RJ, Brazil

4. National Laboratory for Scientific Computing, 25651-075, Petrópolis, RJ, Brazil

5. Institute of Biomedical Sciences, Federal University of Alfenas, 700 Gabriel Monteiro da Silva St, Alfenas, MG 37130-840, Brazil

6. Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro/RJ, Brazil

7. Laboratory of Physiology, Federal University of Alfenas, 2600 Jovino Fernandes Sales Avenue, Alfenas, MG 37130-840, Brazil

8. LASSBio - Laboratório de Avaliação e Síntese de Substâncias Bioativas, Health Sciences Center, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro/RJ, Brazil

9. Laboratory of Neuropharmacology, Institute of Biological Sciences, University of Brasília, Brasilia, DF 70910-900, Brazil

Abstract

A new series of eight multifunctional thalidomide–donepezil hybrids were synthesized based on the multi-target-directed ligand strategy and evaluated as potential neuroprotective, cholinesterase inhibitors and anti-neuroinflammatory agents against neurodegenerative diseases.

Funder

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00374G

Reference81 articles.

1. Modulation of Inflammation as a Way of Delaying Alzheimer's Disease Progression: The Diet's Role

2. Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

3. Neuroinflammation in Huntington’s Disease: New Insights with 11C-PBR28 PET/MRI

4. Inflammation in multiple sclerosis

5. A proteostatic boost

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Comprehensive Study to Identify Major Metabolites of an Amoxicillin–Sulbactam Hybrid Molecule in Rats and Its Metabolic Pathway Using UPLC-Q-TOF-MS/MS;Metabolites;2022-07-18