5-Methylene N-acyl dihydropyridazinium ions as novel Mannich-type acceptors in 1,4 additions of nucleophiles

Author:

Mari Giacomo12345ORCID,De Crescentini Lucia12345ORCID,Mantellini Fabio12345ORCID,Santeusanio Stefania12345ORCID,Favi Gianfranco12345ORCID

Affiliation:

1. Department of Biomolecular Sciences

2. Section of Organic Chemistry and Organic Natural Compounds

3. University of Urbino “Carlo Bo” Via I Maggetti 24

4. 61029 Urbino (PU)

5. Italy

Abstract

Mannich-type addition reactions of various type of nucleophiles with N-acyliminium ions, generated in situ from 5-methylene-6-methoxy-1,4,5,6-tetrahydropyridazines, in the presence of BF3·OEt2, have been developed.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference44 articles.

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2. W. P. Jencks in Catalysis in Chemistry and Enzymology , Dover , New York , 1987

3. H. Bohme and M.Haake in Iminium Salts in Organic Chemistry; Advances in Organic Chemistry , ed. E. C. Taylor , John Wiley and Sons , New York , 1976 , p. 145

4. Solar Synthesis: Prospects in Visible Light Photocatalysis

5. The advent and development of organocatalysis

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