β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine-Reference-Cited by-同舟云学术

β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

Published:2019 Issue:2 Volume:55 Page:253-256
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wang Hanxuan¹²³⁴⁵,Yang Bing¹²³⁴⁵,Wang Yinglu¹²³⁴⁵,Liu Fen¹²³⁴,Fernández-Tejada Alberto⁶⁷⁸⁹¹⁰^ORCID,Dong Suwei¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs

2. Peking University

3. Beijing 100191

4. China

5. Department of Chemical Biology

6. Chemical Immunology Laboratory

7. CIC bioGUNE

8. Biscay Science and Technology Park

9. 48160 Derio

10. Spain

Abstract

We describe the preparation of a cancer vaccine candidate by conjugating a MUC1 peptide antigen to the β-glucan polysaccharide, which serves both as a carrier and an immune activator.

Funder

Ministry of Science and Technology of the People's Republic of China

Peking University

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C8CC07691J

Reference33 articles.

1. Vaccines, new opportunities for a new society

2. Therapeutic vaccines for cancer: an overview of clinical trials

3. Cancer immunotherapy: moving beyond current vaccines

4. Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

5. Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens

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