Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M-Reference-Cited by-同舟云学术

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M

Published:2020 Issue:38 Volume:18 Page:7608-7634
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Nasser Ahmed A.¹²³⁴⁵,Eissa Ibrahim H.¹²³⁴⁵^ORCID,Oun Mohamed R.¹²³⁴⁵,El-Zahabi Mohamed A.¹²³⁴⁵,Taghour Mohammed S.¹²³⁴⁵,Belal Amany⁶⁷⁸⁹⁵^ORCID,Saleh Abdulrahman M.¹²³⁴⁵,Mehany Ahmed B. M.¹⁰¹¹³⁴⁵,Luesch Hendrik¹²¹³¹⁴¹⁵¹⁶^ORCID,Mostafa Ahmad E.¹⁷²³¹⁸⁵,Afifi Wael M.¹⁷²³¹⁸⁵,Rocca James R.¹²¹³¹⁴¹⁵¹⁹,Mahdy Hazem A.¹²³⁴⁵

Affiliation:

1. Pharmaceutical Medicinal Chemistry & Drug Design Department

2. Faculty of Pharmacy (Boys)

3. Al-Azhar University

4. Cairo 11884

5. Egypt

6. Medicinal Chemistry Department

7. Faculty of Pharmacy

8. Beni-Suef University

9. Beni-Suef 62514

10. Zoology Department

11. Faculty of Science

12. Department of Medicinal Chemistry

13. University of Florida

14. Gainesville

15. USA

16. Center for Natural Products

17. Pharmacognosy and Medicinal Plants Dept.

18. Cairo

19. AMRIS Facility

Abstract

A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR).

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01557A

Reference113 articles.

1. Cancer registration data and quality indicators in low and middle income countries: their interpretation and potential use for the improvement of cancer care

2. Global cancer statistics, 2012

3. WHO , Cancer, Fact sheet, 2018 , http://www.who.int/news-room/fact-sheets/detail/cancer

4. The Hedgehog and Wnt signalling pathways in cancer

5. Development of a series of novel 4-anlinoquinazoline derivatives possessing quinazoline skeleton: Design, synthesis, EGFR kinase inhibitory efficacy, and evaluation of anticancer activities in vitro

Cited by 80 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal;Bioorganic Chemistry;2024-02

2. Chitosan-loaded piperlongumine nanoparticles and kaempferol enhance the anti-cancer action of doxorubicin in targeting of Ehrlich solid adenocarcinoma: in vivo and in silico modeling study;Medical Oncology;2024-01-23

3. Role of heterocycles in inhibition of VEGFR-2 – a recent update (2019–2022);RSC Medicinal Chemistry;2024

4. Computer-aided drug discovery of natural antiviral metabolites as potential SARS-CoV-2 helicase inhibitors;Journal of Chemical Research;2024-01

5. Discovery of new thiazolidine-2,4-dione derivatives as potential VEGFR-2 inhibitors: In vitro and in silico studies;Heliyon;2024-01