Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M-Reference-Cited by-同舟云学术

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M

Published:2020 Issue:38 Volume:18 Page:7608-7634
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Nasser Ahmed A.¹²³⁴⁵,Eissa Ibrahim H.¹²³⁴⁵^ORCID,Oun Mohamed R.¹²³⁴⁵,El-Zahabi Mohamed A.¹²³⁴⁵,Taghour Mohammed S.¹²³⁴⁵,Belal Amany⁶⁷⁸⁹⁵^ORCID,Saleh Abdulrahman M.¹²³⁴⁵,Mehany Ahmed B. M.¹⁰¹¹³⁴⁵,Luesch Hendrik¹²¹³¹⁴¹⁵¹⁶^ORCID,Mostafa Ahmad E.¹⁷²³¹⁸⁵,Afifi Wael M.¹⁷²³¹⁸⁵,Rocca James R.¹²¹³¹⁴¹⁵¹⁹,Mahdy Hazem A.¹²³⁴⁵

Affiliation:

1. Pharmaceutical Medicinal Chemistry & Drug Design Department

2. Faculty of Pharmacy (Boys)

3. Al-Azhar University

4. Cairo 11884

5. Egypt

6. Medicinal Chemistry Department

7. Faculty of Pharmacy

8. Beni-Suef University

9. Beni-Suef 62514

10. Zoology Department

11. Faculty of Science

12. Department of Medicinal Chemistry

13. University of Florida

14. Gainesville

15. USA

16. Center for Natural Products

17. Pharmacognosy and Medicinal Plants Dept.

18. Cairo

19. AMRIS Facility

Abstract

A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR).

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01557A

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