Non-hydrogen bond catalyst-mediated diastereoselective conjugate additions of 5H-oxazol-4-ones to o-hydroxyphenyl-substituted p-quinone methides-Reference-Cited by-同舟云学术

Non-hydrogen bond catalyst-mediated diastereoselective conjugate additions of 5H-oxazol-4-ones to o-hydroxyphenyl-substituted p-quinone methides

Published:2020 Issue:35 Volume:18 Page:6807-6811
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Ziyang¹²³⁴⁵,Huang Anqi¹²³⁴⁵,Fang Fang⁶⁷⁸⁵,Li Pengfei⁶⁷⁸⁵^ORCID,Liu Guokai⁹¹⁰¹¹¹²⁵^ORCID,Li Wenjun¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Qingdao University

4. Qingdao 266021

5. China

6. Department of Chemistry and Shenzhen Key Laboratory of Marine Archaea Geo-Omics

7. Southern University of Science and Technology

8. Shenzhen 518055

9. School of Pharmaceutical Sciences

10. Shenzhen University Health Science Centre

11. Shenzhen University

12. Shenzhen 518060

Abstract

An efficient DBU-catalyzed conjugate addition of 5H-oxazol-4-ones to o-hydroxyphenyl-substituted p-quinone methides has been developed, affording the valuable diarylmethanes in high yields with excellent diastereoselectivity.

Funder

National Natural Science Foundation of China

Taishan Scholar Foundation of Shandong Province

Natural Science Foundation of Shandong Province

Science, Technology and Innovation Commission of Shenzhen Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01558J

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