Efficient and scalable total synthesis of calcitroic acid and its 13C-labeled derivative
Author:
Affiliation:
1. HES-SO Haute école spécialisée de Suisse occidentale
2. Ecole d'ingénieurs et d'architectes de Fribourg
3. Institute ChemTech
4. CH-1700 Fribourg, Switzerland
Abstract
Calcitroic acid and its 13C labeled derivative has been synthesized from Inhoffen-Lythgoe diol in 11 steps with an overall yield of 21%.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA04322G
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4. Synthesis of calcitroic acid, a metabolite of 1.alpha.,25-dihydroxycholecalciferol
5. Unsaturated steroids. Part 12. Synthesis of 1α,3β-dihydroxy-24-nor-9,10-secochola-5,7,10(19)trien-23-oic (calcitroic) acid and of the cholic-and 25-homocholic acid analogues
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