ROS-responsive curcumin-encapsulated nanoparticles for AKI therapy <i>via</i> promoting lipid degradation in renal tubules-Reference-Cited by-同舟云学术

ROS-responsive curcumin-encapsulated nanoparticles for AKI therapy via promoting lipid degradation in renal tubules

Published:2024 Issue:12 Volume:12 Page:3063-3078
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Guo Honglei¹,Lan Tianyu²^ORCID,Lu Xin³,Geng Kedui³,Shen Xiangchun³,Mao Huijuan¹,Guo Qianqian³^ORCID

Affiliation:

1. Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, China

2. College of Ethnic Medicine, Guizhou Minzu University, Guiyang 550025, Guizhou Province, China

3. The State Key Laboratory of Functions and Applications of MediEucal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou 550025, China

Abstract

A drug delivery system (NPSBG@Cur) has been developed to respond to ROS and deliver the autophagy activator curcumin (Cur) to reduce the severity of AKI. This system works by activating autophagy and promoting the degradation of lipid droplets.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guizhou Province

Guizhou Medical University

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02318D

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5. Lipidomics Reveals Cisplatin-Induced Renal Lipid Alterations during Acute Kidney Injury and Their Attenuation by Cilastatin

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