Exenatide loaded PLGA microspheres for long-acting antidiabetic therapy: preparation, characterization, pharmacokinetics and pharmacodynamics-Reference-Cited by-同舟云学术

Exenatide loaded PLGA microspheres for long-acting antidiabetic therapy: preparation, characterization, pharmacokinetics and pharmacodynamics

Published:2016 Issue:44 Volume:6 Page:37452-37462
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Yutong¹²³⁴⁵,Sun Ting¹²³⁴⁵,Zhang Yue¹²³⁴⁵,Chaurasiya Birendra¹²³⁴⁵,Huang Liping¹²³⁴⁵,Liu Xi¹²³⁴⁵,Tu Jiasheng¹²³⁴⁵,Xiong Yerong¹²³⁴⁵,Sun Chunmeng¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Natural Medicines

2. Department of Pharmaceutics

3. School of Pharmacy

4. China Pharmaceutical University

5. Nanjing 210009

Abstract

We herein fabricated the exenatide-loaded microspheres by a water in oil in oil (W/O/O) method, which presented great effect on glycemic control with low initial burst release and reduced risk of gastrointestinal intolerance and hypoglycemia.

Funder

National Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA02994A

Reference53 articles.

1. Comparative studies on exenatide-loaded poly ( d , l -lactic-co-glycolic acid) microparticles prepared by a novel ultra-fine particle processing system and spray drying

2. Retaining Antibodies in Tumors with a Self-Assembling Injectable System