Doxorubicin-loaded DNA origami nanostructures: stability in vitreous and their uptake and toxicity in ocular cells-Reference-Cited by-同舟云学术

Doxorubicin-loaded DNA origami nanostructures: stability in vitreous and their uptake and toxicity in ocular cells

Published:2024 Issue: Volume: Page:
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Klose Anna¹^ORCID,Gounani Zahra¹^ORCID,Ijäs Heini²^ORCID,Lajunen Tatu¹³^ORCID,Linko Veikko²⁴^ORCID,Laaksonen Timo¹⁵^ORCID

Affiliation:

1. Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5, 00790 Helsinki, Finland

2. Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, 00076 Aalto, Finland

3. School of Pharmacy, University of Eastern Finland, Yliopistonrinne 3, 70210 Kuopio, Finland

4. Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia

5. Chemistry and Advanced Materials, Faculty of Engineering and Natural Sciences, Tampere University, Korkeakoulunkatu 8, 33720 Tampere, Finland

Abstract

Doxorubicin-loaded DNA origami required additional Mg2+ to be stable in cell medium and vitreous at 37 °C. In retinal epithelial cells (ARPE-19), they were well-tolerated, but limited in their uptake.

Funder

Joint Programming Initiative on Antimicrobial Resistance

Academy of Finland

Suomen Kulttuurirahasto

H2020 European Research Council

Emil Aaltosen Säätiö

Sigrid Juséliuksen Säätiö

Jane ja Aatos Erkon Säätiö

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D4NR01995D

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