Novel biodegradable heparin-coated nanocomposite system for targeted drug delivery

Abstract

HP–SPIO NPs (42 nm) were formulated by co-precipitation. Doxorubicin and paclitaxel were loaded into the SPIO NP core. HP–SPIO NPs had sustained release of DOX (87%) and PTX (75%) at pH 6.0. Drug loaded HP–SPIO NPs caused 95 and 84%, and 85 and 77% apoptosis in A2780 and OVCAR-3 cells, respectively. DOX–HP–SPIO NPs and PTX–HP–SPIO NPs caused a sharp decrease in bcl-2 and survivin proteins.