Biomimetic enterobactin analogue mediates iron-uptake and cargo transport into E. coli and P. aeruginosa-Reference-Cited by-同舟云学术

Biomimetic enterobactin analogue mediates iron-uptake and cargo transport into E. coli and P. aeruginosa

Published:2021 Issue:30 Volume:12 Page:10179-10190
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zscherp Robert¹²³⁴,Coetzee Janetta⁵⁶⁷⁸⁴,Vornweg Johannes¹²³⁴^ORCID,Grunenberg Jörg¹²³⁴,Herrmann Jennifer⁵⁶⁷⁸⁴,Müller Rolf⁵⁶⁷⁸⁴,Klahn Philipp¹²³⁴^ORCID

Affiliation:

1. Institute of Organic Chemistry

2. Technische Universität Braunschweig

3. D-38106 Braunschweig

4. Germany

5. Department for Microbial Natural Products

6. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

7. Helmholtz Center for Infection Research and Department of Pharmacy at Universität des Saarlandes

8. D-66123 Saarbrücken

Abstract

The design, synthesis and evaluation of the enterobactin derivative (AcO)EntKL is reported, which mediates iron uptake and cargo transport into E. coli and P. aeruginosa and was able to compete with human enterobactin and iron binding proteins.

Funder

Deutsche Forschungsgemeinschaft

Niedersächsische Ministerium für Wissenschaft und Kultur

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02084F

Reference115 articles.

1. Antibiotic resistance is ancient

2. Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials