Crystal engineering of nutraceutical phytosterols: new cocrystal solid solutions

Author:

Barbas Rafael12345ORCID,Bofill Lídia675,de Sande Dafne12345,Font-Bardia Mercè8235,Prohens Rafel12345ORCID

Affiliation:

1. Unitat de Polimorfisme i Calorimetria

2. Centres Científics i Tecnològics

3. Universitat de Barcelona

4. 08028 Barcelona

5. Spain

6. Center for Intelligent Research in Crystal Engineering S.L.

7. Palma de Mallorca

8. Unitat de Difracció de Raigs X

Abstract

A cocrystal screening of solid solutions of three phytosterols (β-sitosterol, campesterol, stigmasterol) reveals that cocrystal solid solutions are enriched with β-sitosterol with respect to stigmasterol, a natural product with cytotoxicity concerns.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Reference31 articles.

1. V. Piironen and A. M.Lampi , Phytosterols as functional food components and nutraceuticals , New York , 2004

2. Reduction of Cholesterol Absorption by Dietary Plant Sterols and Stanols in Mice Is Independent of the Abcg5/8 Transporter

3. FDA authorizes new coronary heart disease health claim for plant sterol and plant stanol esters. http://www.cfscan.fda.gov/~lrd/tpsterol.html . (accessed April 2020 )

4. β-Sitosterol Reverses Multidrug Resistance via BCRP Suppression by Inhibiting the p53–MDM2 Interaction in Colorectal Cancer

5. Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications

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