Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases-Reference-Cited by-同舟云学术

Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases

Published:2019 Issue:46 Volume:55 Page:6610-6613
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liu Can¹²³⁴,Yuan Hong⁵⁶⁷⁴,Liao Fei¹²³⁴,Wei Chuan-Wan¹²³⁴,Du Ke-Jie¹²³⁴,Gao Shu-Qin⁸²³⁴,Tan Xiangshi⁵⁶⁷⁴^ORCID,Lin Ying-Wu¹²³⁴⁸^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering

2. University of South China

3. Hengyang 421001

4. China

5. Department of Chemistry & Institute of Biomedical Science

6. Fudan University

7. Shanghai 200433

8. Laboratory of Protein Structure and Function

Abstract

A rationally designed enzyme of F43Y/T67R myoglobin formed unique Tyr-heme double cross-links between Tyr43 and the heme 4-vinyl group, and exhibited a peroxidase activity comparable to that of native peroxidases.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC02714A

Reference47 articles.

1. Design of functional metalloproteins

2. Designing artificial enzymes by intuition and computation

3. Interfacial metal coordination in engineered protein and peptide assemblies

4. Metalloenzyme design and engineering through strategic modifications of native protein scaffolds

5. Recent achievments in the design and engineering of artificial metalloenzymes

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