Implementation of micelle-enabled C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-electrophile coupling in pharmaceutical synthesis-Reference-Cited by-同舟云学术

Implementation of micelle-enabled C(sp²)–C(sp³) cross-electrophile coupling in pharmaceutical synthesis

Published:2024 Issue:17 Volume:60 Page:2349-2352
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wu Bin¹,Ye Ning¹,Zhao Kangming¹^ORCID,Shi Min¹,Liao Jiayu¹,Zhang Jing¹,Chen Wei¹,Li Xianzhong¹,Han Yufeng¹,Cortes-Clerget Margery²,Regnier Morgan Louis²,Parmentier Michael²^ORCID,Mathes Christian²,Rampf Florian²,Gallou Fabrice²^ORCID

Affiliation:

1. Chemical & Analytical Development, Suzhou Novartis Technical Development Co., Ltd, Changshu, Jiangsu 215537, China

2. Chemical & Analytical Development, Novartis Pharma AG, 4056 Basel, Switzerland

Abstract

A sustainable C(sp2)–C(sp3) cross-electrophile coupling was developed between readily available 5-bromophthalide and 1-benzyl-4-iodopiperidine under micellar conditions, leading to a key intermediate of one of our development compounds.

Funder

Novartis

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC05916B

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