Microwave-assisted synthesis of highly sulfated mannuronate glycans as potential inhibitors against SARS-CoV-2-Reference-Cited by-同舟云学术

Microwave-assisted synthesis of highly sulfated mannuronate glycans as potential inhibitors against SARS-CoV-2

Published:2024 Issue:19 Volume:22 Page:3986-3994
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhu Yirong¹,Wang Xiaotong¹,Lu Siqian¹,Zheng Jibin¹,Liang Youling¹,Zhang Liangliang¹,Fang Pengfei²^ORCID,Xu Peng²^ORCID,Yu Biao²,Yang You¹^ORCID

Affiliation:

1. Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

2. State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

Abstract

Sulfated mannuronate glycans with up to 17 sulfation sites were synthesized using a microwave-assisted approach and evaluated as inhibitors against SARS-CoV-2.

Funder

Shanghai Municipal Education Commission

Taishan Industrial Experts Programme

National Natural Science Foundation of China

Opening Project of Shanghai Key Laboratory of New Drug Design

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00466C

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