Practical synthesis of isoindolines yields potent colistin potentiators for multidrug-resistant Acinetobacter baumannii

Author:

Dutta Somnath1ORCID,Eyolfson Samantha1,Zhu Yuhang1,Gao Yuefeng1,Wang Xiang1ORCID

Affiliation:

1. Department of Chemistry, University of Colorado Boulder, Boulder, 80309, USA

Abstract

Implementing isoindole umpolung, diverse isoindoline derivatives are obtained with good yields via one-pot transition metal-free mild-condition reduction. 3k and 3n were found to resensitize multidrug-resistant A. baumannii to colistin.

Publisher

Royal Society of Chemistry (RSC)

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