Interactions in protein solutions close to liquid–liquid phase separation: ethanol reduces attractions via changes of the dielectric solution properties-Reference-Cited by-同舟云学术

Interactions in protein solutions close to liquid–liquid phase separation: ethanol reduces attractions via changes of the dielectric solution properties

Published:2021 Issue:39 Volume:23 Page:22384-22394
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Hansen Jan¹^ORCID,Uthayakumar Rajeevann¹,Pedersen Jan Skov²^ORCID,Egelhaaf Stefan U.¹^ORCID,Platten Florian¹³^ORCID

Affiliation:

1. Condensed Matter Physics Laboratory, Heinrich Heine University, Universitätsstraße 1, 40225 Düsseldorf, Germany

2. iNANO Interdisciplinary Nanoscience Center and Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark

3. Institute of Biological Information Processing (IBI-4: Biomacromolecular Systems and Processes), Forschungszentrum Jülich, Wilhelm-Johnen-Straße, 52428 Jülich, Germany

Abstract

Adding a moderate amount of ethanol to a protein solution weakens the net inter-protein attraction and thus changes the LLPS binodal and the SAXS intensity. The effect can be entirely accounted for by considering the dielectric solution properties.

Funder

Heinrich-Heine-Universität Düsseldorf

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP03210K

Reference119 articles.

1. Liquid-Liquid Phase Separation in Biology

2. Polymer physics of intracellular phase transitions