A facile I2-catalyzed synthesis of imidazo[1,2-a]pyridines via sp3 C–H functionalization of azaarenes and evaluation of anticancer activity-Reference-Cited by-同舟云学术

A facile I2-catalyzed synthesis of imidazo[1,2-a]pyridines via sp3 C–H functionalization of azaarenes and evaluation of anticancer activity

Published:2017 Issue:32 Volume:15 Page:6780-6791
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mani Geeta Sai¹²³⁴⁵,Shaik Siddiq Pasha⁵⁶⁷⁴,Tangella Yellaiah⁵⁶⁷⁴,Bale Swarna¹²³⁴,Godugu Chandraiah¹²³⁴,Kamal Ahmed¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. National Institute of Pharmaceutical Education and Research (NIPER)

3. Hyderabad-500 037

4. India

5. Medicinal Chemistry & Pharmacology

6. CSIR-Indian Institute of Chemical Technology

7. Hyderabad 500 007

Abstract

A three component synthetic protocol has been developed for the synthesis of medicinally important imidazo[1,2-a]pyridines via the iodine-catalyzed oxidative amination of benzylic C–H bonds of azaarenes. The synthesized compounds were evaluated for their anti-cancer activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01384A

Reference93 articles.

1. Silver catalyzed domino aza-annulation/Diels–Alder cyclization of 2-ene-yne anilines: a facile one-pot access to carbazole, dihydrocarbazole and tetrahydrocarbazole frameworks

2. Diphenylphosphoryl Azide (DPPA)-Mediated One-Pot Synthesis of Oxazolo[4,5-c ][1,8]naphthyridin-4(5 H )-ones, Oxazolo[4,5-c ]quinoline-4(5 H )-ones, and Tosyloxazol-5-yl Pyridines

3. One-Pot, Three-Component Approach to the Synthesis of 3,4,5-Trisubstituted Pyrazoles

4. Synthesis of 11C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography

5. Regioselective, Molecular Iodine-Mediated C3 Iodination of Quinolines

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