Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots-Reference-Cited by-同舟云学术

Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots

Published:2019 Issue:23 Volume:10 Page:5884-5892
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Benyettou Farah¹²³,Prakasam Thirumurugan¹²³^ORCID,Ramdas Nair Anjana⁴²³,Witzel Ini-Isabee⁵²³^ORCID,Alhashimi Marwa¹²³,Skorjanc Tina¹²³,Olsen John-Carl⁶⁷⁸⁹,Sadler Kirsten C.⁴²³^ORCID,Trabolsi Ali¹²³^ORCID

Affiliation:

1. Program in Chemistry

2. New York University Abu Dhabi

3. UAE

4. Program in Biology

5. Core Technology Platform

6. Department of Chemistry

7. University of Rochester

8. New York

9. USA

Abstract

A set of metal–organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells––including those resistant to cisplatin––and in zebrafish embryos.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC01218D

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