Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity-Reference-Cited by-同舟云学术

Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Silva-Reis Sara C.¹²^ORCID,Costa Vera M.²³,da Silva Daniela Correia⁴,Pereira David M.⁴^ORCID,Correia Xavier Cruz¹^ORCID,García-Mera Xerardo⁵^ORCID,Rodríguez-Borges José E.¹^ORCID,Sampaio-Dias Ivo E.¹^ORCID

Affiliation:

1. LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal

2. UCIBIO/REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal

3. Associate Laboratory i4HB – Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal

4. LAQV/REQUIMTE, Laboratory of Pharmacognosy, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal

5. Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain

Abstract

A series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.

Funder

Xunta de Galicia

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00584H

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