Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation-Reference-Cited by-同舟云学术

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation

Published:2020 Issue:46 Volume:49 Page:16887-16902
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Enyedy Éva A.¹²³⁴⁵^ORCID,May Nóra V.⁶⁷⁸⁵^ORCID,Pape Veronika F. S.⁹⁷⁸⁵¹⁰^ORCID,Heffeter Petra¹¹¹²¹³¹⁴¹⁵^ORCID,Szakács Gergely⁹⁷⁸⁵¹¹^ORCID,Keppler Bernhard K.¹⁵¹³¹⁴¹⁶¹⁷,Kowol Christian R.¹⁵¹³¹⁴¹⁶¹⁷^ORCID

Affiliation:

1. Department of Inorganic and Analytical Chemistry

2. Interdisciplinary Excellence Centre

3. University of Szeged

4. H-6720 Szeged

5. Hungary

6. Chemical Crystallography Research Group

7. Research Centre for Natural Sciences

8. H-1117 Budapest

9. Institute of Enzymology

10. Department of Physiology

11. Institute of Cancer Research

12. Medical University of Vienna

13. A-1090 Vienna

14. Austria

15. Research Cluster ‘Translational Cancer Therapy Research’

16. Institute of Inorganic Chemistry

17. Faculty of Chemistry

Abstract

Effect of exchange of S to O or Se in Triapine and methylation of the hydrazone NH on the pK_a, lipophilicity, solution stability and redox properties of Cu(ii), Fe(ii) and Fe(iii) complexes and their anticancer activity.

Funder

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Emberi Eroforrások Minisztériuma

Magyar Tudományos Akadémia

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT03465G

Reference58 articles.