Evaluation of drug release from polymeric nanoparticles in simulated saliva and gastric media by asymmetric flow field–flow fractionation (AF4)-Reference-Cited by-同舟云学术

Evaluation of drug release from polymeric nanoparticles in simulated saliva and gastric media by asymmetric flow field–flow fractionation (AF4)

Published:2024 Issue: Volume: Page:
ISSN:2976-8713
Container-title:RSC Pharmaceutics
language:en
Short-container-title:RSC Pharm.

Author:

Wu Haoran¹^ORCID,Homawoo Alaia²,Shariati Saba³,Astete Carlos E.⁴^ORCID,Rodrigues Debora F.¹^ORCID,Sabliov Cristina M.⁴,Fini Elham H.³,Louie Stacey M.¹^ORCID

Affiliation:

1. Department of Civil & Environmental Engineering, University of Houston, Houston, TX 77004, USA

2. Department of Electrical & Computer Engineering, University of Houston, Houston, TX 77004, USA

3. School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85287, USA

4. Department of Biological & Agricultural Engineering, Louisiana State University, Baton Rouge, LA 70803, USA

Abstract

Enrofloxacin release from PLGA nanocarriers was evaluated in simulated saliva and gastric fluid. AF4 and DFT analyses revealed that acidic solvent intrusion above Tg induced faster diffusive release, whereas media proteins had no significant effect.

Funder

National Institute of Food and Agriculture

U.S. Department of Agriculture

National Institute of Standards and Technology

FMC Corporation

Ecolab

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/PM/D4PM00175C

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