In vivo metal-catalyzed SeCT therapy by a proapoptotic peptide

Author:

Ahmadi Peni1,Muguruma Kyohei2,Chang Tsung-Che1,Tamura Satoru3,Tsubokura Kazuki1,Egawa Yasuko1,Suzuki Takehiro4,Dohmae Naoshi4,Nakao Yoichi5,Tanaka Katsunori126ORCID

Affiliation:

1. Biofunctional Synthetic Chemistry, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

2. Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan

3. Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University, Yahaba, Iwate 028-3694, Japan

4. Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

5. School of Advanced Science and Engineering, Department of Chemistry and Biochemistry, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan

6. Biofunctional Chemistry Laboratory, A. Butlerov Institute of Chemistry, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, Russia

Abstract

The combination of a proapoptotic peptide with covalent tagging and a carrier-Ru-complex inhibited tumor growth in mice after a single injection.

Funder

Japan Society for the Promotion of Science

Astellas Pharma

Japan Agency for Medical Research and Development

Mizutani Foundation for Glycoscience

Kazan Federal University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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