Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions
Author:
Affiliation:
1. LaCBio – Laboratory of Biomimetic Catalysis
2. Department of Chemistry
3. Federal University of Santa Catarina – UFSC
4. 88040-900 Florianópolis
5. Brazil
6. University of Cambridge
7. CB2 1EW Cambridge
8. UK
9. Instituto de Medicina Molecular
Abstract
This review assesses the mechanistic aspects of transition metal-mediated uncaging reactions, with the goal of aiding the rational development of new caging groups/catalysts for chemical biology and drug-delivery applications.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação para a Ciência e a Tecnologia
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/CS/D0CS00630K
Reference72 articles.
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3. Dissociative Bioorthogonal Reactions
4. Transition-metal-mediated uncaging in living human cells — an emerging alternative to photolabile protecting groups
5. Chemistry in living systems
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