A biscoumarin scaffold as an efficient anti-Zika virus lead with NS3-helicase inhibitory potential: in vitro and in silico investigations-Reference-Cited by-同舟云学术

A biscoumarin scaffold as an efficient anti-Zika virus lead with NS3-helicase inhibitory potential: in vitro and in silico investigations

Published:2020 Issue:5 Volume:44 Page:1872-1880
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Mayank ¹²,Kumar Deepak³²,Kaur Navneet⁴⁵²^ORCID,Giri Rajanish³²^ORCID,Singh Narinder¹²^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Ropar

2. India

3. School of Basic Sciences, Indian Institute of Technology Mandi

4. Department of Chemistry

5. Chandigarh

Abstract

Competitive NTPase inhibition and the potential binding to the RNA binding pocket of Zika NS3-helicase were observed using biscoumarin derivatives. The SAR was established, and MN-9 and MN-10 were identified as potent anti-Zika leads.

Funder

Department of Science and Technology, Ministry of Science and Technology

Department of Biotechnology, Ministry of Science and Technology

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/C9NJ05225A

Reference36 articles.

1. Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus

2. History, Epidemiology, and Clinical Manifestations of Zika: A Systematic Review

3. The Known Unknowns of Emerging Viruses

4. Detecting Vertical Zika Transmission: Emerging Diagnostic Approaches for an Emerged Flavivirus

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