Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells

Author:

Lombe Blaise Kimbadi12345ORCID,Feineis Doris1234,Mudogo Virima5678,Brun Reto910111213,Awale Suresh1415161718ORCID,Bringmann Gerhard1234ORCID

Affiliation:

1. Institute of Organic Chemistry

2. University of Würzburg

3. D-97074 Würzburg

4. Germany

5. Faculté des Sciences

6. Université de Kinshasa

7. Kinshasa XI

8. Democratic Republic of the Congo

9. Swiss Tropical and Public Health Institute

10. CH-4002 Basel

11. Switzerland

12. University of Basel

13. CH-4003 Basel

14. Division of Natural Drug Discovery

15. Institute of Natural Medicine

16. University of Toyoma

17. Toyama 930-0194

18. Japan

Abstract

The first dimers of 5,8′-coupled naphthylisoquinolines with two 1,3-cis-configured tetrahydroisoquinoline portions and their cytotoxicities against cancer cells are described.

Funder

Deutscher Akademischer Austauschdienst

Deutsche Forschungsgemeinschaft

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference33 articles.

1. G.Bringmann and F.Pokorny , in The Alkaloids , ed. G. A. Cordell , Academic Press Inc , New York , 1995 , vol. 46 , pp. 127–271

2. Naphthylisoquinoline alkaloids potential drug leads

3. Ancistrocladus Benomensis (Ancistrocladaceae): A New Species from Peninsular Malaysia

4. Ancistrocladus ileboensis (D.R.Congo), a new liana with unique alkaloids

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