Aqueous RAFT synthesis of block and statistical copolymers of 2-(α-d-mannopyranosyloxy)ethyl methacrylate with 2-(N,N-dimethylamino)ethyl methacrylate and their application for nonviral gene delivery

Author:

Obata Makoto1234,Kobori Tomoya1234,Hirohara Shiho5674,Tanihara Masao89104

Affiliation:

1. Interdisciplinary Graduate School of Medicine and Engineering

2. University of Yamanashi

3. Kofu 400-8510

4. Japan

5. Department of Chemical and Biological Engineering

6. Ube National College of Technology

7. Ube 755-8555

8. Graduate School of Materials Science

9. Nara Institute of Science and Technology

10. Nara 630-0192

Abstract

Statistical and block glycopolymers presenting d-mannose were prepared by aqueous RAFT polymerization, and the effect of the microstructure on gene delivery was examined.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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